Aim of study:__ampersandsignnbsp;The study was aimed at collecting data on traditional use and assessing conservation statuses of some of the Caucasus endemic medicinal plants confined to limestone habitats. Materials and Methods:__ampersandsignnbsp;The data used in the study are a part of floristic investigations conducted from 1996 to 2008 in different parts Imereti, West Georgia (the Caucasus Biodiversity Hotspot). Data on distribution, ecology, population state (rare, scarce, common), threats collected by the author were used for IUCN Red List assessment of the four target species. Results:__ampersandsignnbsp;Conservation statuses of the four target species used in traditional medicine were assessed as follows: Corylus imeretica Kem.-Nath., Potentilla imerethica Gagnidze and__ampersandsignnbsp;M. Sochadze (endemic to Imereti)__ampersandsignnbsp;__ampersandsignndash;__ampersandsignnbsp;VU;__ampersandsignnbsp;Cyclamen colchicum (Albov)__ampersandsignnbsp;Albov (endemic to Georgia)__ampersandsignnbsp;__ampersandsignndash;__ampersandsignnbsp;VU;__ampersandsignnbsp;Quercus imeretina Stev. ex Woronow (endemic to the Caucasus)__ampersandsignnbsp;__ampersandsignndash;__ampersandsignnbsp;VU. Conclusions:__ampersandsignnbsp;The presented species need to be more thoroughly studied for their active compounds to justify the traditional usage of the species and search for possibilities of their use in modern medicine. Since natural resources of these species are limited and their populations experience negative effects of various factors acting as threats, relevant conservation measures are to be elaborated to protect their populations that may occur an important source for obtaining compounds with a potential to be used in medicine.