Introduction: Accurate diagnosis of skin is of utmost importance for management of different skin disorders presenting with the similar clinical signs and symptoms. Therefore to confirm the diagnosis and start treatment biopsy becomes inevitable and for obtaining diagnostic full-thickness skin specimens Punch biopsy is the primary method. Aims __ampersandsignamp; Objective: The present study was to analyse the incidence and age __ampersandsignamp; sex distribution of dermatological disorders presenting to B.J. Medical College, Civil Hospital Ahmedabad (tertiary care centre), Gujarat and access their histopathological profile Materials __ampersandsignamp; Methods: This was a retrospective study carried out at the department of Pathology B.J. Medical College __ampersandsignamp; Civil Hospital, Ahmedabad for a period of 1 year (1st January 2016 to 31st December 2016). With necessary clinical details obtained in a proforma, punch biopsy specimen is sent to the histopathology section for final diagnosis. Formalin fixed, paraffin embedded sections were prepared __ampersandsignamp; slides were routinely stained with H __ampersandsignamp; E and special stains applied wherever necessary. Data obtained was tabulated and analysed Results: Total 232 cases were analysed. 21-30 years age group constituted 22% of the total cases. Male/Female ratio is 61/39. Hypopigmented patch/plaque was the most common clinical lesion (27%). Hansen__ampersandsignrsquo;s disease was the most common histopathological diagnosis reported (30%) followed by vesiculobullous lesions (12%). Conclusion: Punch biopsy is a very simple outdoor procedure and very useful for skin lesions. Hansen__ampersandsignrsquo;s disease is still most common skin disease for which biopsy is done followed by vesiculobullous lesion. Tattoo induced granuloma is also a common lesion along with lichenoid lesion.