Aim: Dengue is the arboviral febrile illness, which affects the vascular, muscular and hematological systems. Thrombocytopenia is one of the criteria used by WHO guidelines as a potential indicator of clinical severity of infection. Along with that hepatic dysfunction is a well-recognized feature of dengue infection characterized by hepatomegaly and increased serum transaminase levels. Aim of this study was To Assess the liver involvement in dengue infection during critical period of illness by correlating liver transaminase enzymes levels with platelet count in Tertiary care hospital in Western India. Methods: 80 dengue patients were divided into Group A of 40 cases of dengue with platelet count less than 100000/cmm and Group B of 40 cases of dengue with platelet count more than 100000/cmm. 40 age and gender matched healthy controls were taken into Group C. Under all aseptic precautions, 2 ml of blood sample was collected from ante-cubital vein without occlusion in EDTA vacutainer and 1 ml in plain vacutainer. Separated serum was subjected for measurement of serum AST (Aspartate Transaminase) and ALT (Alanine Transaminase). Whole Blood from EDTA was used for Platelet Count Measurement. Results: In our study we found levels of AST and ALT were higher in Group A and Group B compared to group C. Mean AST and ALT levels were much higher in group A as compared to group B. Also abnormality in AST levels is higher than ALT in both group A and group B. AST and ALT level __ampersandsigngt; 1000 IU/L were recorded only in group A and not in group B which suggests that severe hepatic dysfunction in terms of rise in AST and ALT are mostly seen in patients with platelet count __ampersandsignlt;1,00,000 /cmm during critical period of illness. When we correlated AST and ALT with platelet count in group A and group B, we found negative correlation between them in both groups. When we correlated platelet count with AST and ALT in all dengue patients irrespective of platelet count, we got not only negative correlation between them but also this correlation was statistically significant Conclusion: Our study concludes that transaminase levels increases in almost all dengue patients. The rise in AST and ALT level increases with increase in dengue severity which is indicated by fall in platelet count as they are negatively correlated with each other. But this negative correlation cannot be used to differentiate dengue patients with platelet count __ampersandsignlt;1,00,000 /cmm and __ampersandsigngt; 1,00000/cmm. So liver damage is one of the common complications of dengue and AST as well as ALT levels should be used as biochemical markers in those patients to detect and monitor hepatic dysfunction.