Self-medication is a common practice in developing countries, including Egypt, but little is known about its epidemiology as well as the future plan needed to overcome this problem. This future perspective article aimed to describe the current situation of this problem in Egypt and the prospective vision of the author about this problem and the future plan needed for its prevention and control. Egyptian literatures in English language about self medication from 1995 onwards were searched through a web-based medical database during September, 2015 and articles concerned with this issue was retrieved and reviewed. The reviewed literatures, although sparse, showed a considerable high prevalence of medication abuse among Egyptian population in the recent years which was as high as 86.4% in certain Egyptian governorate. Moreover, there has been lack of studies about other epidemiologic aspects of this problem in terms of its distribution and determinants, its health and economic impacts, and its prevention and control strategies. The present article pays the attention of public health personnel, university and medical researchers to carry out more studies and to increase awareness of general population, students, senior physicians, pharmacists, and organizations about this serious public health problem. In addition, the author presented his prospective view to combat this problem through short and long-term preventive and control plan.