Background: Stroke is defined as an acute neurological deficit lasting more than 24 hours and caused by cerebrovascular etiology. It is further subdivided into ischemic stroke (caused by vascular occlusion or stenosis) and hemorrhagic stroke (caused by vascular rupture, resulting in intra parenchymal and/or subarachnoid hemorrhage). Aim: Our study was designed to study the levels of High sensitivity C reactive protein (HsCRP), which is a marker for chronic inflammation, in patients with ischemic stroke due to large vessel atherosclerosis and correlate it with carotid intimal medial thickness. Methodology: This study was done in Department of Medicine and Department of neurology in KGMU, Lucknow, between August 2016 to July 2017, and 100 patients with ischemic stroke presenting within 72 hours of onset, who met the inclusion and exclusion criteria. HsCRP was evaluated and CIMT was subsequently measured. Result: HsCRP is significantly increased in patients with ischemic stroke. The carotid intimal medial thickness which is a proven marker for large artery atherosclerosis is also increased in patients with ischemic stroke and it is also significantly correlated with the levels of HsCRP. The levels of HsCRP is elevated more in patients with Diabetes Mellitus and Hypertension. Conclusion: HsCRP levels are increased in patients of ischemic stroke suggesting that it could be used as a marker for the prediction of the ischemic stroke when combined with CIMT, together these two could predict the ischemic stroke.