Background: Some problems related to migraine as one of the most common causes of headache is caused by psychiatric disorders associated with it. Understanding relation between personality disorders with migraine headache can be effective in the diagnosis and treatment of migraine. Aim: The aim of this study was to investigate the association between personality characteristics and migraine incidence in neurology clinic in Ardabil during 2013-14. Methods: In this descriptive-analytical study, 50 migraine patients were selected randomly. In order to determine personality disorders, MCMI-3 questionnaire was used. Collected data analyzed using statistical methods in SPSS.16. Results: Of all patients,62% were female and 38% were male with the mean age of 37.02 years old (range 18-65). The personality disorders that observed among patients by the highest frequency order were histrionic personality disorder (70%) and obsessive (40%). The prevalence of depressive personality disorder among women (P = 0.020) and the prevalence of narcissistic personality disorder higher among men (P = 0.049) were significantly higher than others. Conclusion: Results showed that people with migraines have certain personality characteristics such as anxiety, irritation, depression, anxiety, and obsession that these characteristics leads into internal frustration and cause to headache and finally lead to migraine headache.