A 25 years old female patient presented with history of recurrent seizures since 2 years. Patient was diagnosed as a case of Neurocysticercosis based on Magnetic resonant imaging (MRI) of brain finding in January 2015 for which she was given a course of Albendazole, Prednisolone and antiepileptic medications. During the following 2 year period, patient developed recurrent seizures and abnormal behavior for which patient was investigated and new neurocysticercosis lesions were found in MRI Brain despite previous complete antiparasitic treatment and adherence to diet and antiepileptic medication. Patient had received courses of Albendazole (4 times) with combination of Ivermectin (1 time), and with course of Praziquantel (1 time). So we are reporting this rare case of neurocysticercosis resistant to conventional, routinely used antihelminthic medications.