Background: Stroke is a major public health problem contributing to significant morbidity and mortality across the globe. In spite of many reviews documenting a strong association between stroke and depression, it is the most ignored aspect in many developing countries including India, due to paucity of studies on the subject. Hence the current study was conducted with an objective of assessing the prevalence of depression among the stroke patients and factors influencing it in a tertiary care teaching hospital Materials __ampersandsignamp; Methods: This cross sectional study was conducted in the department of Neurology and the department of Psychiatry in NRI General Hospital. The study had included 56 eligible stroke patients and evaluated them for depression using DSM-IV TR Diagnostic criteria and Hamilton Depression Rating Scale (HAM-D). Results: The prevalence of depression in study population was 46.4%, out of which 21.4% had minor depression and 25% had major depression. The demographic factors which have shown increased risk of depression were female gender, primary school educational status, middle socioeconomic class and living in an extended nuclear family or joint family. But none of the associations had shown statistical significance. The disease related factors associated with increased risk of stroke were presence of aphasia, severe limitation of and presence of stressful life event. Out of these only severe limitation of ADL has shown statistically significant association. Conclusions: The prevalence of depression is very high in patients affected by stroke. The major factors which were associated with increased risk of depression were female gender, presence of aphasia, severe limitation of ADL and presence of stressful life events.