Background: This study proposes to see whether end stage renal disease (ESRD) patients undergoing haemodialysis with additional diabetes mellitus exhibit increased cardiovascular risk markers in comparison to end stage renal disease (ESRD) patients undergoing haemodialysis without diabetes mellitus. Objectives: In this study, an attempt has been made to compare the Lipid profile and fibrinogen as inflammatory markers for assessing cardiovascular risk between diabetic and non-diabetic end stage renal disease (ESRD) patients undergoing maintenance haemodialysis. Material and Methods: We enrolled 32 patients of both sex suffering from diabetes mellitus end stage renal disease undergoing haemodialysis and 32 non- diabetic end stage renal disease undergoing haemodialysis for this study. Results: We found that there is significant increase in the parameters like plasma fibrinogen, plasma glucose concentration, atherogenic index (TC/HDLc), serum lipid profile (TC, LDLc, TG, VLDLc) and decrease in serum HDLc in diabetic ESRD patients in comparison to non diabetic ESRD patients undergoing maintenance haemodialysis. Conclusion: We conclude that elevation in plasma fibrinogen level, serum lipid profile and atherogenic index (TC/HDLc) in diabetic ESRD patients undergoing maintenance haemodialysis which indicates higher risk of adverse cardiac events and atherosclerosis as a major cause of coronary heart disease in diabetic ESRD patients.