Sepsis is one of the challenges for the doctors who treat critically ill patients. Delay in diagnosis and late administration of antibiotics have been shown to increase the mortality in this cohort. Objective: This study was done to evaluate whether microalbuminuria can be used as a marker of sepsis and also to compare with the levels of C-reactive protein (CRP a traditional marker) of patients admitted in ICU. The study was carried out in the department of Biochemistry, B.J. Medical College and Sassoon general hospitals, Pune. Method: 50 adult patients with ICU stay of more than 24 hrs were included in the study. 50 healthy and age, sex matched controls were also included in the study. Patients with pregnancy, menstruation, anuria, macroscopic hematuria, urinary tract infection, any renal disorder and marked proteinuria were excluded from the study. Blood and spot urine samples were collected on admission and after 24 hrs. Urinary microalbumin was measured in terms of albumin creatinine ratio (ACR) and serum CRP levels were measured on ICU admission (ACR1,CRP1) and after 24 hrs (ACR2,CRP2). Results and Conclusion: In the study we observed that there was a marked correlation between ACR1 and CRP1 (r=0.786) and also ACR2 and CRP2 (0.787). There was a significant increase in the values of both the parameters on admission as compared to controls (p__ampersandsignlt;0.001). Out of 50 patients, 35 showed increased levels of ACR and CRP levels whereas 15 showed decreased levels after 24 hrs. Patients showing decreased levels had better prognosis as compared to those showing increased levels. Thus we can conclude that ACR can be an effective marker for early detection of sepsis and can also be used to monitor the severity of the disease.