Introduction: Chemicals in cigarette smoke have been implicated in causing subclinical changes in myelin sheaths of peripheral nerves. This may contribute to nerve dysfunction particularly in the form of decreases in nerve conduction velocity. The degree of this effect has not been clearly established Aim and Objective: To measure nerve conduction velocity in the median nerve in smokers and nonsmokers. Study Design: This was a cross-sectional case-control study involving 80 normal healthy subjects (age range, 25-40 years). There were 40 apparently healthy smokers and 40 healthy non-smokers. Conduction velocities were measured in motor and sensory components of the median nerve under similar conditions. Data was analyzed by using appropriate statistical methods. Results: Statistically significant changes (P __ampersandsignlt; 0.05) were found in the sensory nerve conduction velocity (Mean+ SD value in smokers was 55.11+ 2.32 m/s while in nonsmokers it was 57.09+ 4.21 m/s) whereas no such changes were found in Motor nerve conduction velocity (Mean+ SD value in smokers was 54.19 +6.35 m/s while in nonsmokers it was 54.97+ 7.33 m/s) in this study. Conclusion: We conclude that chronic smoking results in reduction of conduction velocities in sensory fibers of the median nerve.