Schizophrenia is a severe disorder affecting the brain. Defective neurotransmitters and altered neurotransmission system maybe one of the various causes for this psychiatric disease. There are several hypotheses explaining the development of schizophrenia. However, recently the role of oxidative stress and inflammation causing some irreversible alterations in the brain tissue are an explanation to the development of schizophrenia. Oxidative stress is a condition caused due to imbalance between the excessively produced free radicals and antioxidant system of the body. The brain is vulnerable to the damage caused by oxidative stress indicated by elevated levels of biomarkers of oxidative stress. There are research studies confirming the undoubted effects of antipsychotics treatment on the oxidative stress prevalent in schizophrenic patients. The interplay of cytokines, interleukins and T-cells in inflammation causes development of elevated levels of free radicals which are potentially toxic to the neurons. Thus increased oxidative stress triggers inflammation whereas redox balance causes inhibition of cellular response. The brain is protected form toxic free radicals by the inherent antioxidant defense mechanism. The current therapeutic modality suggests the synergistic action of omega -3- fatty acids intake in the diet as well as regular doses of antipsychotics taken in combination as a treatment of Schizophrenia. The omega -3-fatty acids affects and elevates the antioxidant defense mechanisms in schizophrenic patients. This will improve the schizophrenic disease condition, status and further prognosis.