Introduction: Diseases of prostate gland are important source of morbidity and mortality in male patients. The spectrum of diseases consists of inflammatory conditions, nodular hyperplasia, malignancy etc. The risk of diseases increases with age. Prostate biopsy is essentially a test which detects cancer and other benign conditions of the prostate in patients who have specific indications for it. Other modalities of diagnosis also have been developed, comprising of radiological modalities and prostatic biomarkers. However, biopsy with histopathological examination is the gold standard for the final diagnosis. Aims and Objective: To study various histopathological patterns in Transurethral resection of prostate(TURP) and needle biopsy of prostate, including benign prostatic hyperplasia(BPH), prostatitis (identifying type and grade of inflammation),incidental detection of carcinoma prostate and confirmation of diagnosis of clinically suspected carcinoma with application of modified Gleason system for grading. Materials and Methods: Total 100 cases of prostatic lesions including transurethral resection of prostate(TURP) and needle biopsy were evaluated in this study. The received specimens were fixed in 10% neutral buffered formalin and routine paraffin processing followed by hematoxyline and eosin staining was done. All the specimens were analysed with following parameters: type of specimen, age of patient, histopathological pattern and final diagnosis. Results: In total 100 cases of present study, the most common age group presenting prostatic lesions was 61-70 years. The youngest patient presenting with prostatic lesion was 45 years age, and oldest was of 85 years of age. In this, various histopathological patterns observed were- Benign prostatic hyperplasia (BPH)in 45%,benign prostatic hyperplasia (BPH)with co-existing chronic prostatitis in 10%, granulomatous prostatitis 1% (single case),acute prostatitis 3% and acute on chronic prostatitis 6%.Less frequent finding were benign prostatic hyperplasia (BPH)with basal cell hyperplasia 1%,benign prostatic hyperplasia (BPH)with squamous metaplasia 2%,benign prostatic hyperplasia (BPH)with clear cell changes 3% and some of biopsy show only stromal tissue with hyperplasia in 4%.We reported 7 cases of adenocarcinoma prostate with application of modified Gleason grading system. Conclusion: Benign lesions are more common than malignant lesions. Among the histological patterns of prostatic lesions, benign prostatic hyperplasia (BPH)is predominant type. It is necessary to study all prostate biopsy [Transurethral resection of prostate(TURP)and needle] in order to identify premalignant lesions, proliferative activity, and grade of inflammation. Histopathological diagnosis and grading plays a definitive role in the management of prostatic cancer.