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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2348</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url">10.7324/IJCRR.2017.9206</article-id><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>Histopathological Study of Ocular Surface Squamous Neoplasia in Biopsies Received at Tertiary Care Centre&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Desai</surname><given-names>Neetal</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Ami</given-names></name></contrib><contrib contrib-type="author"><name><surname>Goswami</surname><given-names>Hansa</given-names></name></contrib></contrib-group><volume>)</volume><issue/><fpage>24</fpage><lpage>29</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>Introduction: Ocular surface squamous neoplasia(OSSN) is an encompassing term for pre-cancerous and cancerous epithelial lesions of the conjunctiva and cornea which includes Dysplasia, Carcinoma in-situ (CIS) and Invasive Squamous Cell Carcinoma. OSSN is mostly unilateral, occurs in middle aged to older patients. It is associated with factors such as HIV and xeroderma pigmentosum.&#13;
Aims and Objectives:&#13;
1) To evaluate incidence of Dysplasia and Squamous Cell Carcinoma in biopsies received&#13;
2) To study the spectrum of histopathological findings in Ocular Surface Squamous Neoplasia&#13;
Materials and Method: We examined 52 ocular surface biopsies received in our tertiary care centre during the period of 22 months (August-2015 to May-2017). Slides stained with Hematoxylin and Eosin were examined and dysplasia found in biopsies were categorized into mild, moderate and severe. Invasive squamous cell carcinomas were again categorized according to differentiation into well differentiated, moderately differentiated and poorly differentiated. In addition to these 52 biopsies, 10 biopsies were excluded from the study which showed normal or only hyperplastic squamous epithelium.&#13;
Results: Out of 52 biopsies examined, 2 cases showed squamous papilloma,13 cases showed dysplasia-mild being the commonest and 37 cases showed invasive carcinoma, moderate differentiation being the commonest.&#13;
Conclusion: OSSN is common in middle age and male gender and usually occurs in limbal conjunctiva. Histopathology remains the gold standard for accurate diagnosis and grading of OSSN. Despite increasing awareness, Invasive carcinoma is more prevalent than dysplasia. Prognosis largely depends upon grade and differentiation of tumor and specific microscopic type.&#13;
</p></abstract><kwd-group><kwd>Dysplasia</kwd><kwd> Squamous Cell Carcinoma</kwd><kwd> HIV</kwd><kwd> Xeroderma Pigmentosum</kwd></kwd-group></article-meta></front></article>
