Aim: To determine the effectiveness of moderate and high intensity exercise on maximum oxygen consumption and health related quality of life among type 2 diabetes mellitus participants. Method: In this study 10 individuals with type 2 diabetes mellitus were selected based on inclusion and exclusion criteria. They are divided into two groups by Odd and Even method. Group A content of 5 participants, received moderate intensity exercise and group B content of 5 participants, received high intensity exercise. Outcomes are maximum oxygen consumption and health related quality of life were taken at the baseline and 4 weeks after the treatment. Both the groups participants continued their medications during study period. Results: The post-test mean __ampersandsignplusmn;SD value of VO2max for Group-A is 38.64__ampersandsignplusmn;4.18 and for Group-B is 47.98__ampersandsignplusmn;5.58 this shows that Group-B is greater than Group A with P value 0.0171(p __ampersandsignlt;.05).The post-test mean __ampersandsignplusmn;SD value of Health Related Quality Of Life for Group A is 9.80__ampersandsignplusmn;1.92 and for Group-B is 6.60__ampersandsignplusmn;1.14 this shows that Group-B is improved than Group-A. Conclusions: This study concludes that high intensity exercise is better intervention to improve Maximum Oxygen Consumption (VO2max) and improve Health Related Quality of Life (HRQoL) in Type 2 diabetes mellitus as compared to moderate intensity exercise.