IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy234HealthcareSYNTHESIS AND APPLICATIONS OF SUGAR FLUORINATED NUCLEOSIDES ElzagheidMohamed Ibrahim12072016)4249This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

In this review, different methods that have been used for the synthesis of 1__ampersandsignrsquo;-, 2__ampersandsignrsquo;-, 3__ampersandsignrsquo;-, 4__ampersandsignrsquo;- and 5__ampersandsignrsquo;-sugar fluorinated nucleosides and their analogous are presented and different fluorinating agents are listed. Highlighted examples of the sugar fluorinated nucleosides that make a great impact on chemistry, biochemistry, and drug discovery are also elaborated. This review has shown that introduction of a fluorine atom in different positions within the sugar structure of the nucleoside improves their reactivity and properties.

Nucleosides synthesis and applications Sugar fluorinated nucleosides Fluorinating agents