Introduction: Chronic dacryocystitis is a common presentation in our outpatient department. We explored the possibility of an effective and minimally invasive procedure for the treatment of this disease. The underlying pathophysiology of chronic dacryocystitis is nasolacrimal duct obstruction. We designed a study to evaluate the clinical outcome and complications of nasolacrimal duct probing as a therapeutic procedure for the treatment of chronic dacryocystitis in adults. Nasolacrimal duct probing is effective in the treatment of congenital nasolacrimal duct obstruction. We report the results of nasolacrimal duct probing in adults. Aim: Clinical outcome and complications of nasolacrimal duct probing in adult cases of chronic dacryocystitis seen at a regional Institute of Ophthalmology. Methodology: 100 consecutive cases of chronic dacryocystitis fitting into the study criteria were enrolled. The patients were subjected to a thorough preoperative examination and subsequent nasolacrimal duct probing under standard conditions. The patients were subjected to a strict postoperative regime and were followed up for three months. Result: Nasolacrimal duct probing was successful (both subjectively and objectively) in 98 out of 100 patients with chronic dacryocystitis. Discussion: We report successful treatment of adult cases of chronic dacryocystitis by nasolacrimal duct probing. Conclusion: We conclude that adults with chronic dacryocystitis can be managed successfully with nasolacrimal duct probing.