Introduction: Amoebic peritonitis is due to the rupture of amoebic liver abscess or perforation of amoebic colitis. Amoebic peritonitis is associated with very high mortality. Methodology: A case of amoebic peritonitis is reported in a young adult female with live cirrhosis. The diagnosis of amoebic peritonitis was established by the demonstration of trophozoites in the ascitic fluid and significant titres in indirect haemagglutination test. Result: Cytopathological examination of peritoneal fluid showed presence of large number of trophozoites of E. histolytica. Anti E. histolytica serum antibodies by indirect haemagglutination(IHA) were present in titres 1:320. Conclusion: A high index of suspicion in any case of colitis along with serological testing is indicated for the early diagnosis and timely management.