Objectives: The present study was conducted with aim to generate the clinico-epidemiological data of Acute Poisoning cases presented at hospital which in turn would be helpful in planning rational use of available resources for prevention and management of poisoning cases. Methods: Observational cross-sectional study was carried out from October, 2013 to March, 2014. Patients of either sex of above 12 years of age of acute poisoning admitted in medicine emergency ward were included. Obtained data were analyzed using descriptive statistics and results were expressed as percentage and mean. Results: Of 340 cases, male and female patients were 216(63.53%) and 124(36.47%) respectively. Male: female ratio was 1.74:1. Most of the cases belonged to the age group of 21-30 years (38.82%). Ingestion was the most common route of exposure (71.47%). Intentional (suicidal) poisoning was recorded in 62.06% cases followed by accidental poisoning (37.94%). Common causes of poisoning were poisonous bites (25.88%) followed by organophosphate (19.41%) and unknown compound (19.41%) ingestion. Commonly observed symptoms were vomiting, local symptoms in cases of bites, altered sensorium, giddiness and breathing difficulty. Average number of days of hospitalization was 5.39 days. Complete recovery and mortality were seen in 66.47% and 16.47% cases respectively. Conclusion: Acute Poisoning is one of the leading causes of hospital admissions and mortalities. High costs of treatment and intensive care burden makes poisoning an important area for further research. The current study has managed to contribute substantial additional information regarding the epidemiology and outcome of poisoning in a tertiary care hospital at a district level.