Aim: This study provides an insight into the assessment of the treatment pattern, clinical outcome and quality of life in patients with Bladder outlet obstruction and to assess the safety and efficacy of (0.2 mg) and (0.4 mg) tamsulosin in female patients with Bladder outlet obstruction in a tertiary care teachinghospital. Method: Institutional ethics committee approval was obtained from kasturba hospital, Manipal for conducting this study.This was a randomised controlled study conducted for eight months at Dept. of Urology, Kasturba Hospital, Manipal. Inclusion criteria were all male bpatients in age group greater than 45years with bladder outlet obstruction symptoms due to BPH and all the female patients aged greater than 35 years with bladder outlet obstruction were included for the study. Exclusion criteria were allMale patients with Stricture urethra, acute cystitis, Carcinoma of prostate, Neurogenic voiding dysfunction and all female patients with Pelvic masses, previous pelvic surgery, and acute cystitis were excluded from the study. The American Urological Association Symptom Score (AUASS) was adopted to assess the severity of urinary symptoms and to check the effectiveness of the treatment. The percentage of improvement of treatment was also assessed in terms of both objective and subjective parameters like Maximum Flow Rate (MFR), Post Voidal Residual Volume (PVR) and bladder thickness. Female patients were randomised into two groups? first group of patients receiving (0.2 mg of tamsulosin) while second group of patients receiving (0.4 mg of tamsulosin) daily for a period of months with periodic follow up at 2nd , 4 th and 8 th week, assessed with IPSS (International Prostate Symptom Score) and uroflowmetry andultrasonography at 8 th week. The quality of life in patients with bladder outlet obstruction was evaluated by using the quality of life questionnaire. Results: A total number of 177 patients diagnosed with bladder outletobstruction were aged between 55 to 65 years and males (n=152) predominated over females (n=25). Weak stream urinary symptoms were found to be the highest complained symptom. The co morbidities associated with bladder outlet obstruction was Hypertension. Surgery was the main line of treatment in patients with bladder outlet obstruction. The drug tamsulosin was the most implicated drug in the medical group. The most common surgical procedure performed was transurethral resection of the prostate. The safety and efficacy of tamsulosin in female patients showed that patients were having AUASS score between 8-19 (moderate) before treatment and most of them showed an improvement in the score from moderate to mild (1-7) aftertreatment. The subjective parameters showed that the female patients had an MFR value of __ampersandsignlt; 15ml/s before treatment and have improved after treatment from __ampersandsignlt; 15ml/s to __ampersandsigngt;15ml/s. The PVR values were __ampersandsigngt;50ml in all patients before treatment and __ampersandsignlt; 50ml after treatment. The bladder thickness showed a reduction from __ampersandsigngt; 5mm to __ampersandsignlt; 2.5mm. Our results show tamsulosin to be very effective in the management of bladder outlet obstruction in female patient if detected early. Conclusions: In female patients? use of tamsulosin was found to be a very safe, well tolerated showing significant improvement in urinary outflow symptoms, reducing post void urinevolume and decreasing IPSS with minimal tolerable adverse events. The correct and timely diagnosis of bladder outlet obstruction in women was difficult, since clinical features are similar to those of other voidingdisorders and diagnostic modalities are often inconclusive or even misleading.