IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy2280HealthcareDERIVATIVE SPECTROPHOTOMETRIC ESTIMATION OF NEVIRAPINE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS K.Jawade S.S.G.KhanageP.B.MohiteV.K.Deshmukh1727This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

A simple, accurate and precise spectrophotometric method has been developed and validated for the estimation of nevirapine from bulk drug and tablet formulations. Nevirapine shows a sharp peak at 241.0 nm in first order derivative spectrum with n =1. The drug follow Beer-Lambert?s law in the concentration range of 4-24 __ampersandsignmu;g/ml in this method. Result of the analysis was validated statistically and found accurate. The method was successfully applied for determination of drug in tablets, wherein no interference from tablet excipients was observed, indicating the specificity of the developed method. Thus the proposed method can be used successfully for routine analysis of nevirapine from capsule and tablet formulations.

Nevirapine Ultraviolate Spectroscopy Derivative spectroscopy validation precise accurate .