Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. The anatomy, physiology and biochemistry of the eye render this organ exquisitely impervious to foreign substances. The challenge to the formulator is to circumvent the protective barriers of the eye without causing permanent tissue damage. Newer delivery system is being explored to develop extended duration and controlled release strategy. Some of the newer, sensitive and successful ocular delivery system like inserts, biodegradable polymeric system, and collagen shields are being developed in order to attain better ocular bioavailability and sustained action of ocular drugs.