Objective: In the present study, fast dispersing tablets of Diclofenac Sodium were prepared by using natural super disintegrants obtained from husk and mucilage of seeds of plant Lepidium sativum. Fast dispersing or dissolving tablets are the dosage form which dissolve or disintegrate in oral cavity without the need of water or chewing. Diclofenac Sodium is a non steroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic in conditions such as arthritis or acute injury with lower indication of gastrointestinal adverse effects. Method: The husk and mucilage were obtained from the seeds. The physicochemical properties like density, flow properties, particle size distribution, swelling index and water uptake studies of dried husk and mucilage were evaluated. It was observed that it shows rapid water uptake and swelling which makes it suitable candidate as disintegrants. Diclofenac Sodium fast dispersing tablets have been prepared by direct compression method by using mucilage and husk of the seeds of plant Lepidium sativum. Formulation was optimized on the basis of physical properties, swelling time, drug content, in vitro disintegration and in vitro drug release. The study revealed that husk and mucilage are effective at 4% concentration and showed rapid disintegration of the tablets (25 sec and 22 sec respectively). The husk as well as the mucilage did not interfere with the in vitro release studies. The tablets show almost complete release within 20 minutes. Conclusion: From this study, it can be concluded that natural disintegrants obtained from Lepidium sativum showed fast disintegrating property.