Physicians prescribing pattern of oral antidiabetic drugs may be key to avoid the serious complications of patients suffering from type 2 diabetes. However, fixed dose combinations were often prescribed to achieve target glycemic levels. Treatment complexity can be reduced by prescribing a fixed dose combination of two or more oral antidiabetic drugs. There are good numbers of studies which suggest the use of fixed dose combinations not only to reduce the complications of diabetes but also to improve adherence. A variety of fixed dose combination oral antidiabetic drugs in different dosage strengths are available and the strategies for selecting such fixed dose combinations options depends on physicians prescribing behavior and patients condition. This article describes the increasing preference of physicians to prescribe fixed dose combinations of oral antidiabetic drugs.