Ketorolac is an NSAID. It is indicated for short term management of moderate to moderately severe acute pain, including post surgical pain , acute musculoskeletal trauma pain and post partum uterine cramping pain. The biological half life of ketorolac is 3-6 hrs, hence lower doses of ketorolac are required as loading dose and higher doses as maintenance dose. Therefore, it is considered as a suitable drug for the formulation of sustained release matrix tablets to prolong its therapeutic action. In the Present work, studies were carried on the preparation and evaluation of matrix tablets of ketorolac using hydrophilic swellable polymers (HPMC K4M __ampersandsign K15M, Guar gum) and Eudragit (RSPO) with a view to obtain sustain release characteristic to achieve prolonged therapeutic effect by continuously releasing medication over a extended period of time after administration of single dose. The dissolution result shows that an increased amount of polymer resulted in retarded drug release. A concentration dependent drug release is evident in case of the polymer i.e., lower concentration of polymers, release is marginally retarded at higher concentration is considerable. Our prepared matrix formulation containing Eudragit (RSPO) 10 % is probably showing better release based on 80 –90 % drug release within 8 -9 hours, which is the average G.I. residence time.