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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2220</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url"/><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>A REVIEW OF FLOATING DRUG DELIVERY SYSTEM&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>K.</surname><given-names>Jawale S.</given-names></name></contrib><contrib contrib-type="author"><name><surname/><given-names/></name></contrib><contrib contrib-type="author"><name><surname/><given-names/></name></contrib><contrib contrib-type="author"><name><surname>V.K.</surname><given-names>Deshmukh</given-names></name></contrib></contrib-group><volume/><issue/><fpage>40</fpage><lpage>47</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, drug is released slowly at a desired rate from the system. After release of drug, the residual system is emptied from the stomach. This results in an increased Gastric Residence Time (GRT) and a better control of fluctuations in plasma drug concentration. The system must have sufficient structure to form a cohesive gel barrier to maintain an overall specific gravity lower than that of gastric contents and to dissolve slowly enough to serve as a drug reservoir. Based on the mechanism of buoyancy, two distinctly different technologies, i.e. noneffervescent and effervescent systems, have been utilized in the development of FDDS.&#13;
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