In India, neonatal infections occurs in 10.97 to 27 per thousand live births and is the leading cause of neonatal mortality accounting for one quarter to nearly half of all neonatal deaths. A detailed clinical profile of 155 early onset neonatal infections was carried out prospectively for 12 months. Almost 70% babies had associated risk factors. Refusal to feed, respiratory distress, lethargy, restlessness, irritability, hypothermia and fever were the most common presenting features in that order. Blood culture was positive in 71(68.93%) cases. Klebsiella pneumoniae was the most frequently isolated pathogen (61.97%). CRP positivity, increased micro-ESR concentration and associated thrombocytopenia were present in statistically significant number of cases. It can be concluded from the findings of the study that some routine inexpensive laboratory tests will help in the early diagnosis of neonatal septicaemia.