The present investigation concerns about the development of the colloidal dispersion of mucoadhesive polymers containing Domperidone for intranasal delivery. Colloidal dispersion was prepared by sonication method and was characterized. Methylcellulose, Hydroxypropyl methylcellulose and Chitosan were used as a release retardant material. The nasal isotonic buffer was prepared after calculating the Sodium chloride displacement (E value) of the ingredients and was used as a vehicle. E values were calculated from L iso values. The effects of HPMC and Chitosan on drug release profile were investigated. In the study it was found that HPMC has synergistic effect on viscosity and bioadhesive strength when used in combination with methyl cellulose. Formulations were evaluated for in vitro drug release profile, Appearance, pH examination, Drug content estimation In-vitro Bioadhesion studies at different contact times, for selection of the best batch. Formulation batch F2 was the optimized and was further studied for Histopathological examination and accelerated stability.