Piroxicam is a Non-steroidal anti inflammatory, analgesic and anti-pyretic drug. This is widely used in Muscular-skeletal disorder like osteoarthritis. Piroxicam has bitter taste, half life of 30 hrs and poor water solubility. So the present work was focused on masking the bitter taste of piroxicam. In the present research was to develop the taste-masked microspheres of bitter drug piroxicam by spray-drying technique. The bitter taste threshold value of piroxicam was determined. Three different polymers viz. low molecular Chitosan, high molecular Chitosan and Pluronic F127 were used for piroxicam microsphere formation, and the effect of different polymers and drug__ampersandsignndash;polymer ratios on the taste masking and release properties of microspheres was investigated. The microspheres were characterized by Fourier transform infrared spectroscopy, Differential scanning colorimetric, scanning electron microscopy, Drug loading, in vitro bitter taste evaluation, and drug-release properties. The taste masking was found absent in low molecular chitosan microspheres at 1:1 drug__ampersandsignndash;polymer ratios. The high molecular chitosan microspheres showed taste masking at 1:2 drug__ampersandsignndash;polymer ratio, whereas with Pluronic F127 microspheres the taste masking was not achieved at all the drug__ampersandsignndash; polymer ratio. The drug release was about 53.34% for low molecular chitosan microspheres and 39.57% for high molecular Chitosan microspheres in 15 min. hence spray dried microspheres can be effective technique for taste masking of bitter drugs without affecting the drug property.