Aqueous and ethanolic extract of Chirayita (Swertia chirayita Linn.) were screened for their antibacteria activity Methicillin Resistant Staphylococcus aureus (MRSA). Kirby Bauer__ampersandsignlsquo;s Disk Diffusion method an Broth Serial Dilution method according to CLSI Guidelines by W.H.O were used. It was compared with the Standard drug-Vancomycin and Plane control-DMSO (the solvent used). The Resistant drug__ampersandsignndash; Methicillin was also used to confirm the resistance of MRSA strains used. The prepared plates were incubated and results were evaluated by measuring the Zone of Inhibition - ZOI (in mm.) of drug extract. MIC and MBC was also carried out against the resistant strain. All the experiments were conducted in triplicates and in sterilized conditions. The results were analyzed statistically using gpaid software and it was found that MRSA strain was sensitive to S.chirayita showing a significant ZOI as compared to the standard drug. Present investigation indicates that S.chirayita possesses antimicrobial properties and hence can be used for future natural plant based antimicrobial agents. Thus the study provides an in-vitro proof of its antibacterial activity against MRSA. However further investigations are needed to find out its pharmacological details and to make it fit for use, for the welfare of humankind. So, that it can be used against the infectious diseases caused by the resistant strain of Staphylococcus aureus safely and effectively.