Objective: However Coronary Artery Disease (CAD) is the leading cause of death worldwide, there is a scarcity of data on effectiveness of exercise-based cardiac rehabilitation programs on myocardial contractility as predictor of long term prognosis and so the present study aimed to investigate the same in post coronary event patients. Methods: In a Single blinded, Randomized controlled trial, Post-Coronary event CAD patients with age group of 35 to 75 years, surgically (CABG or PTCA) or conservatively treated were recruited from Golsar Hospital; Iran. Exclusion criteria were high risk group (AACVPR-99) patients and any contraindication to exercise testing and training. Recruited patients were randomized either into Hospitalbased, Home-based cardiac rehabilitation or Control by means of block randomization (block size of 6) and concealed envelope method. Patients in the study group [Hospital (HsCR) and Home-based(HmCR)] underwent 12 weeks individually tailored exercise-based cardiac rehabilitation according to the ACSM- 2005 guidelines. Control group only received the usual cardiac care without any exercise training. Myocardial contractility in terms of LVEF was measured by echocardiography before and after 12 weeks of exercise training in both groups as well as control. Differences between and within groups were analyzed using one way ANOVA keeping level of significance at 0.05. Results: 42 patients having given written, informed consent with mean age of 59.8__ampersandsignplusmn; 9.0 enrolled. There was a significant increase in LVEF in both study groups (48.2__ampersandsignplusmn;5.0 to 60.5__ampersandsignplusmn;4.0 in HsCR and 47.2__ampersandsignplusmn; 6.3 to 60.5__ampersandsignplusmn;3.4 in HmCR) group compare to control (48.4__ampersandsignplusmn; 6.8 to 48.6__ampersandsignplusmn;7.4) group (p__ampersandsignlt;0.0001). Conclusion: 12 weeks early (within one month post-discharge) structured individually tailored cardiac rehabilitation significantly improved LVEF in post coronary event patients.