Objectives: To evaluate the antimicrobial efficacy of curcumin against E. faecalis considering Sodium hypochlorite (3%) as references for comparison. Methods: The antibacterial efficacy of a 100% pure solution of curcumin was evaluated against planktonic cells of E.fecalis using three tests: zone of inhibition, Minimum inhibitory and bactericidal concentrations, and time taken to kill the cells, The data were statistically analysed by one-way ANOVA and post hoc Tukey HSD test (p=0.05). Results: The result revealed that curcumin had significant antibacterial activity against E.fecalis The zones of inhibition of curcumin against E.fecalis was 32 __ampersandsignplusmn; 4 mm, which was significantly different from the standard - vancomycin, while the zone of inhibition for sodium hypochlorite was 34 __ampersandsignplusmn; 5mm. There was no significant difference between the aforementioned data for sodium hypochlorite and curcumin (P __ampersandsigngt; 0.05) Tube dilution test revealed that MIC and MBC of curcumin were 625 __ampersandsignmu;g/mL and 2.5 mg/mL respectively. While NaOCl, achieved 100% killing of E.fecalis at 2 minutes, curcumin was able to achieve the same in 5 minutes. Conclusions: The antibacterial activity of curcumin was similar to sodium hypochlorite . Considering the potential for undesirable properties of NaOCl, the use of herbal alternatives in endodontics might prove to be advantageous.