Many of people around the world enjoy the benefits of technological and economic developments and high standards of living, however, many scientists are aware that these developments cost a lot. Developments of human societies and industry result in bioenvironmental problems; pollution put the water, air and soil resources at risk. The objective of this study is to determine the quality of water in Birjand, a city located in the east of Iran. In this context, it was determined the factors of pH, total hardness, alkalinity, calcium, manganese, potassium, sulphate, ammonium, nitrite, cyanide, chlorine at seven stations. The Results showed that the concentration of pH, total hardness and ammonium were at 7.76, 348.09 and 0.06 mg/L, respectively. The mean concentration of nitrite, magnesium and chlorine were 0.006, 56.38 and 4.95 mg/L, respectively. Also, the mean concentration of cyanide was determined as 1 mg/L. Results also indicated that there were correlations among the measured parameters. Comparing the results with drinking water standards showed that the drinking water in Birjand, based on these parameters, is desirable. However, it belongs to the very hard water. Moreover, the analysis of data displayed a significant difference among the measured parameters in different stations