The weight uniformity, disintegration time, active drug content and bactericidal assays of five brands (A-E) of amoxicillin sodium capsules in Nsukka, Nigeria were evaluated using official methods (BP, 2001). All the five brands passed the disintegration time test with disintegration time range of 240.0-360.0 sec; all the brands passed the weight uniformity test with percentage deviation value range of 1.51-4.27 %. However, only brand D passed the active drug content test with percentage absolute drug content of 103.33%. Brand B has percentage active drug content of 107.39 % which is above the BP and USP specifications. Brands A, C and E failed the active drug content with percentage active drug content of 80.00, 72.00 and 66.67 % respectively. All the brands exhibited comparable bactericidal activity (p__ampersandsignlt;0.05) against Gram positive Staphylococcus aureus and may be used interchangeably.