Background: Acute coronary syndrome is very common course of death worldwide. It is the most common life Threatening cardiological disease. Assessment of prognosis of acute coronary syndrome patient with respect of Uric acid level as a risk factor to prevent mortality and morbidity have great impact on public health. Aim of the study: Very few Literatures are available regarding this. Our objective is to find out the Effect of Serum Uric acid level on short term outcome of acute coronary syndrome patient. Materials and Methods: We did retrospective study in general medicine department of SSKM HOSPITAL; Kolkata, with acute coronary syndrome patients on 2009-2010. Our study included 100 patients of acute coronary syndrome of various severity. We also proposed to do a detailed laboratory investigation including serum uric acid level in every patient. We did Detailed Clinical Examination and Relevant laboratory investigation. We collected Data according to Hospital regulation after approval by Hospital authorities. Then we analyzed data with help of statistical method BY using software. Results: In our study serum uric acid levels correlate with severity of cardiac failure. There was statistically significant correlation found between serum uric had higher levels of uric acid as compared to patients of class l and ll. Discussion: Out of 100 patients, six expired during 7 day follow up. Patients who had myocardial infarction in past have higher serum uric acid levels and are in higher Killip class. Combination of Killip class and serum uric acid level after acute myocardial infarction is a good predictor of mortality after ami. Conclusion: Hyperurecemia is found to be associated with less chance of good outcome of acute coronary syndrome patients.