Objectives: To compare the efficacy and safety of Hemidesmus indicus and ointment of Astragalus hamosus with Tablet Doxycycline and vaginal pessary of Clindamycin and Clotrimazole in endocervicitis. Material and Methods: A randomized standard controlled single blind study was carried out in the Department of Gynecology at the National Institute of Unani Medicine. Clinically diagnosed patients (n=45) were randomized to the test (n=30) and control (n=15) Groups by computer generated random table No. The inclusion criteria were married patients aged 18 to 40 years with symptoms of vaginal discharge, lower abdominal pain, low backache, dysuria, dyspareunia, pruritus vulvae and post coital bleeding. The exclusion criteria were unmarried, pregnant or lactating women, patients with pelvic pathology or malignancy, using oral or intrauterine contraceptive devices, sexually transmitted diseases and concomitant diseases. In the test Group, Majoon Ushba was given 10 gm BD orally and intra-vaginally Marham Nakhuna was applied once daily at night for 15 days after menses for 3 consecutive cycles. In control group, Tablet Doxycycline 100 mg BD was given orally and vaginal pessary of Clindamycin and Clotrimazole OD at night after menses for 7 days for 3 consecutive cycles. The results were analyzed by Kruskal-Wallis with Dunn__ampersandsignlsquo;s multiple comparison, Wilcoxan match pair, Mann Whitney test, Student?t__ampersandsignlsquo; test, Fisher__ampersandsignlsquo;s exact test and Chi-square test. Results: There was a significant improvement in the subjective and objective parameters in both test and control group. The test drugs were found to show more response than the control in the management of endocervicitis with p value__ampersandsignlt;0.05 Conclusion: The test drugs were found to be useful and effective in the management of endocervicitis. Further, the effectiveness should be evaluated in large sample size with recent techniques.