Pre-eclampsia is due to reduced placental perfusion and a consequent maternal disorder characterized by endothelial dysfunction caused by lipid peroxidation due to oxidative stress secondary to reduced placental perfusion. An oxidative stress is said to occur when the peroxidant injury due to lipid peroxides such as Malondialdehyde and secondary degeneration products of lipid peroxidation overwhelms the antioxidant defence. The study was undertaken to find out the levels of Serum Malondialdehyde in Pregnancy induced Hypertension (PIH). A study was carried out among a total of 60 cases of PIH, distributed among the gestational periods of 27-40 weeks. Controls were 75 normal pregnants and 30 non-pregnants. Serum Malondialdehyde (MDA), Serum Total Cholesterol (TC), Serum Triglycerides (TG), Serum High-density Lipoprotein Cholesterol (HDLC), Serum Low-density Lipoprotein Cholesterol (LDLC), Serum Very Low-density Lipoprotein Cholesterol (VLDLC) were estimated. Other investigations done were Urine Protein, Serum Creatinine, Serum Uric acid, Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Bilirubin in support of diagnosis. Malondialdehyde showed a definite increase with increasing period of gestation in normal pregnant controls along with Serum Total Cholesterol, Serum Triglycerides, and Serum Very Low-density Lipoprotein Cholesterol. In non-pregnant controls, Malondialdehyde, Lipids and Lipid sub fractions were within the normal range. Serum Malondialdehyde did not show any definite variation in relation to severity of disease like mild without proteinuria, mild with proteinuria and severe PIH, but showed a definite increase with increasing period of gestation 27-30 weeks, 31-35 weeks and 36-40 weeks. Serum Total Cholesterol, Serum Triglycerides, Serum Very Low-density Lipoprotein cholesterol showed a definite increase with increasing period of gestation in Pregnancy induced Hypertension.