The role of stress in gastrointestinal diseases including peptic ulcer has been known since long time ago. Recently some (such as Lazuras) believe that person__ampersandsignlsquo;s assessment and coping skills have more important role than stress itself . This research was designed to make a comparison between rates of perceived stress in teachers with peptic ulcer vs those without peptic ulcer and determination of effectiveness of __ampersandsignlaquo; Stress Inoculation Training __ampersandsignraquo; program, on perceived stress in patients with peptic ulcer. This was a cross-sectional study. Among 724 primary school teachers of Amol city, a sample of 300 people through __ampersandsignlaquo;Cluster Sampling __ampersandsignraquo;was selected and among 43 people that had peptic ulcer, two groups each included 15 people was choose , one group as case and the other as control . Case group went on the program of __ampersandsignlaquo; Inoculation Training against Stress __ampersandsignraquo;. All sampling stages were randomized and the research design was pretest- posttest with control group type. Perceived Stress was scaled by Interview and __ampersandsignlaquo;Perceived Stress Scale __ampersandsignndash; PSS __ampersandsignraquo; in case and control groups before and after the execution of the procedure on the case group. PSS is normalized in Iran, By Sepahvand and Guilani and Zamani. The results were analyzed by ANCOVA and Independent. The outcome of the study showed that: - Rate of stress in patients with peptic ulcer was more than control group. - Training of inoculation against stress was effective in reduction of perceived stress in patients with peptic ulcer. - There were no statistical meaningful differences between male vs female in mean perceived stress scales. This study showed that inoculation training program against stress in patients with peptic ulcer can reduce perceived stress.