IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy2024General SciencesELIMINATION OF ARSENIC AND SKIN MANIFESTATIONS CAN BE COUNTERACTED BY GENE POLYMORPHISM ChandaSarmishthaDasguptaUma BMazumderDebendranath Guha28122011)8593This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

Glutathione- S -Transferase (GST) might be involved in the initial reduction of arsenate to arsenite and subsequent oxidative methylation (Sampayo 2000, Zakharyan 2001). Humans with null genotype of GST M1 and T1 have been considered to be a high risk group of people who retain arsenic in their body due to incomplete metabolism of arsenic. In order to elucidate the relationship among clinical severity, urinary excretion of arsenic and genetic polymorphisms of GST M1 and T1, a total of 100 study subjects were recruited from the villages of southern region of WestBengal, India. Specimens of drinking water, blood and urine were collected from each study subjects. Concentration of arsenic in urine and water was determined by atomic absorption spectro photometry-hydride generation system. Multiplex polymerase chain reaction (PCR) was performed to determine the genetic polymorphism of GST M1 and T1. Genetic polymorphism of GSTM1 and T1 were significantly associated (p

Arsenic exposure urinary arsenic null genotype clinical severity genetic polymorphism.