Bucholzia coriaceae has been reported in folk medicine to have many medicinal properties including anthelmentic,antimicrobial and antifungal activity. Phytochemical screening of the aqueous and methanol extracts of Bucholzia coriaceae leaves revealed the presence of tannins, reducing sugars, saponins, terpenoids, flavonoids, and cardiac glycosides. The minimum inhibitory concentration (MIC) of the methanol extract was between 0.5 __ampersandsignndash; 7.0 mg/ml while the minimum bactericidal concentration (MBC) ranged from 2.0 __ampersandsignndash; 9.0 mg/ml. The methanol and aqueous extracts exhibited antifungal activity against Candida albicans and Aspergillus niger with zones of inhibition of 11.5 mm and 3.6 mm for Candida albicans ; 9.0 mm and 2.0 mm for Aspergillus niger. The aqueous extract exhibited less antimicrobial effect than the methanol extract.