Background: Disability in leprosy affects the activities of daily life which has got a negative impact on the quality of life. Further due to disability and social stigma there is restriction in participation in social functions. All these factors must be considered while measuring disability and rehabilitation. Objectives: 1) To assess the disability in persons suffering from leprosy and to find out the effect of disability on activities of daily living and social life. Design: A cross sectional descriptive type of study. Subjects: 132 people affected by leprosy, living in leprosy colonies at Bijapur, Karnataka, India were involved in the study. Methodology: A house to house survey and interview was carried out using the standard questionnaire of the Green Pasture__ampersandsignrsquo;s assessment scale. Results: The prevalence of different types of impairments ranged from 31% in Lower Limbs, 35.9% in Upper Limbs and 45.46% in Eyes. The most commonly affected indoor activities were bathing (30.30%), washing hands and feet (30.30%), going to toilet (27.27%), dressing (31.82%), using scissors and knife (33%), eating and drinking (28.23%). Among the outdoor activities affected were cutting grass (51%), ploughing (61%) and carrying water pot (48%). Conclusion: Experiencing severe difficulties with the activities of daily living is a common problem in persons with chronic impairments due to leprosy. This leads to restrictions in social participation and sometimes even isolation as a result of disfigurement and social stigma. The level of difficulty can be assessed and measured using Green Pasture__ampersandsignrsquo;s assessment scale based on subjective difficulty, which could be more helpful in rehabilitation.