Aim: Previous studies show that neuropathic pain is refractory against conventional analgesics and thus novel medicaments are desired for the treatment. Activated K+ channels are associated with reducing inappropriate or excessive neuronal activity. The aim of this study was to__ampersandsignnbsp;investigate the possible analgesic effects of potassium channel opening on neuropathic pain. Therefore, the present study was designed to investigate whether potassium channel activator can generate qualitative analgesic effects on the acute pain induced by thermal and mechanical stimulation. Methods: The effect of diazoxide at the dose of 200 mg/kg on acute thermal and mechanical nociception were assessed by sensory testing like spontaneous pain, mechanical hyperalgesia, tactile as well as cold allodynia in chronic constriction injury (CCI) induced pain in rat. Results: After CCI surgery, the rats developed neuropathic pain syndrome. Behavioral studies demonstrated that rats with the CCI experienced spontaneous pain, dynamic allodynia and mechanical hyperalgesia which were significantly different from the sham group. Treatment with diazoxide decreased significantly the withdrawal durations in all sensory tests. Conclusion: The present study indicates that activity of K+ channel may contribute significantly to the development of central sensitization-mediated pain and suggests that K+ openers may be an important molecular target for the treatment of chronic pain of neuropathic origin.__ampersandsignnbsp;