Byssinosis is an important occupational hazard and a type of pneumoconiosis, often observed among workers exposed to cotton, flax, and Hump dust in the cotton mills. The severity and extent of the problem are well recognized in the developed countries and control measures have been implemented to prevent the disease. This is not true, however, for the developing countries like India, where the severity and extent of the problem are not well studied and preventive measures are virtually non-existent. A review of the earlier studies on Byssinosis suggests a low prevalence of the disease in most of the Indian Textile mills. In this retrospective, epidemiological study carried out on workers in cotton mill / ginning factory of Bijapur district North Karnataka, 110 subjects were examined for different pulmonary function tests to study the prevalence of Byssinosis among the workers exposed to cotton fibers. However, our study showed a high prevalence of the disease, especially in the blow and card sections of the mill. The prevalence of byssinosis was found to be 8.95% among workers directly exposed to cotton dust. Prevalence of their respiratory symptoms among these workers is as follows: chronic cough__ampersandsignnbsp;(19.40%), chronic phlegm (7.46%), and chronic bronchitis (11.94%). The prevalence of byssinosis and other respiratory symptoms increased with increase in duration of exposure and advancement of age and are more prevalent among smokers compared to non-smokers. It can be concluded from the present study that, the exposure to cotton dust results in decreases in pulmonary function parameters in worker at both dusty and non-dusty section of mill, which may result in onset of various respiratory disorders. The overall findings of the study of three textile mills are presented in the present paper.