Click chemistry is a chemical philosophy introduced by K. Barry Sharpless in 2001 and describes chemistry tailored to generate substances quickly and reliably by joining small units together. This is inspired by the fact that nature also generates substances by joining small modular units. Click chemistry is not a specific reaction; it is a concept that mimicks nature. Sustainable development requires redesigning many organic chemical processes, most of which are often based on technology developed in the first half of the 20th century, and inventing new reactions that use and produce safer chemicals under more environmentally benign conditions. Click Chemistry is often cited as a style of chemical synthesis that is consistent with the goals of green chemistry. The focus is on minimizing the hazard and maximizing the efficiency of any chemical choice. Moreover Sharpless notes that ?many of the reactions that meet the click chemistry standard often proceed better (faster and more selectivity) in water than in organic solvents. Click Chemistry requires simple reaction conditions, preferably solvent free or water as the solvent which results in generation of inoffensive by-products. Indeed it has been found that most of the reactions that meet click chemistry standards often proceed rapidly in water and with high yield than in an organic solvent. The aim of the present article is to provide in detail the click chemistry reactions using solvent free or water as the solvent that is consistent with the goals of sustainable chemistry.