FGTB is usually a silent disease evidencing itself only when really looked for. It usually affects females of reproductive age group. Disruption of the IFN-gamma gene in mice infected with M. tuberculosis has resulted in exacerbation of disease, progressive and widespread tissue destruction and necrosis with numerous bacteria. We therefore proposed, to study the possible association of IFN-__ampersandsigngamma; gene polymorphism in Indian women with female genital tuberculosis. It is a prospective case-control study. Screening of genomic DNA samples were carried out from clinically definite 106 FGTB patients and 100 unaffected patients aged between 18 to 40 years. +874 (T?A) IFN-__ampersandsigngamma; genotyping was carried out by using sequence specific primer polymerase chain reaction (SSP-PCR) method. Statistical tests were performed using pantaray software systems. According to our investigation, FGTB patients showed more or less similar TT (30.18% vs. 30.0%), higher AA (19.81% vs. 9.0%) genotypes compared to controls and the frequency of AT genotypes decreased significantly. Distribution of IFN- __ampersandsigngamma; genotypes between patients and controls were have statistical disparity. This study suggests that IFN-__ampersandsigngamma; +874 T to A polymorphism have an etiological association with susceptibility of female genital tuberculosis.