Aim: To evaluate the remineralization efficacy of CPP-ACP and Fluoride Varnish using Diagnodent and to compare the remineralization efficacy of CPP-ACP and Fluoride Varnish. Methodology: Sixty freshly extracted non carious premolars were selected and randomly divided into three groups of twenty samples each. Group A: (Control), Group B: Fluoride Varnish (Fluorprotector), Group C: CPP __ampersandsignndash; ACP (Tooth mousse). The baseline values for all the samples were recorded using__ampersandsignnbsp;diagnodent (KaVo). After demineralizing the samples, values were again measured. Fluorprotector__ampersandsignnbsp;(Ivoclar Vivadent) and GC Tooth mousse (Recaldent) were applied on to the buccal surface of the samples in group B and group C respectively with group A as control. Twenty minutes later the readings for Group B and Group C were obtained. All the samples in the three groups were immersed in artificial saliva and the readings obtained were statistically analyzed. Results: The mean value for group B was (5.6+/-0.9) and for group C was (7.2+/-1.6). This was statistically significant (P__ampersandsignlt;0.0001) and the remineralization was found to be more in CPP-ACP group. Conclusion: CPP-ACP has a statistically significant remineralization potential than fluorprotector. There was no statistical significance when Group A, Group B and Group C were compared individually with artificial saliva.