Sedimental Extract of Tinospora cordifolia (SETc), with no mortality rate at the maximum of 2000mg/kg/p.o., acute dose was found to show maximum number of deaths on chronic treatment in the mid of 28 days repeated oral toxicity study. A trial made on SETc at incremental doses starts from the minimum of 250 - 1000 mg/kg/p.o., were then subjected to modified IDF procedure, to study their safer therapeutic margin. Sprague dawley rats were made diabetic with streptozotocin (45mg/kg/i.p.) and the OGTT procedure was performed on those diabetic rats, fasted around 16 hours prior to the commencement of IDF study. Starting from the 30th min after glucose load (1g/kg/p.o.), the incremental doses of SETc, from the minimum of 250mg/kg/p.o., to the__ampersandsignnbsp;maximum of 1000 mg/kg/p.o., were administered to each group. The reduced blood glucose levels from each group were analyzed and derived by means of AUC and thereby safer therapeutic and effective dose of the test drug was fixed. The onset of action of all the doses of the SETc originates from the 60th min of the drug administration and showed the biological responses in a concentration dependant manner. Based on the IDF, AUC and EDF data__ampersandsignlsquo;s, it was found to be very clear that the dose of 1000 mg/kg/p.o., of SETc was found to underlie the safer therapeutic margin than the other doses. This evidences that the application of this modified method would be a valuable tool for finding safer therapeutic marginal dose using BGC as a key factor.