Objective: The study was designed to assess the effects of isometric handgrip training on cardiovascular system, using handgrip dynamometry and comparing the results between trained and untrained groups. Materials and Methods: Study subjects consisted of 30 healthy adult normotensive medical students in the age group of 18-22 years. Age and sex matched adults who were not active in sports or in physical activities constituted the control group (n= 30) Hemodynamic parameters; blood pressure and heart rate were recorded and evaluated after a defined protocol of handgrip dynamometer at rest and post exercise. BP and HR were recorded with the help of Sphygmomanometer, stethoscope, and ECG machine.There was no change in resting blood pressure and heart rate between the subject and control group before the training sessions. There was significant decrease in resting blood pressure and heart rate in__ampersandsignnbsp;trained subject group when compared to untrained control group after 5 weeks of training sessions.