There is no drug with out any side effect or adverse reaction, adverse drug reaction is an unwanted or harmful reaction experienced following the administration of a drug or combination of drugs under normal conditions of use and suspected to be related to the drug. Hence in dentistry even the orthodontist also should pay a close attention to the drug consumption history of each and every patient. Since many drugs have shown inhibitory effect on tooth movement. The purpose of this article is to describe the drugs which are commonly affecting the rate of tooth movement.