Oral diseases such as Dental caries /plaque and Periodontal diseases are caused by micro organisms belonging to the resident micro flora rather than by classic microbial pathogens. They are caused by the ecological imbalance in oral bio films. In clinical studies, an increasing incidence of incipient carious lesions and generalized gingival inflammation have been found in patients undergoing fixed orthodontic appliance. Oral microbial flora is dominated by gram positive micro organisms and hence dental plaque which is formed on the tooth surface contains gram positive cocci and bacilli. Oral health also influences the general quality of life and poor oral health is linked to chronic conditions and systemic diseases. The association between oral diseases and the oral microbiota is well established. Acidogenic bacteria like Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Streptococcus__ampersandsignnbsp;intermedius, Streptococcus anginosus, Lactobacillus acidophilus, streptococcus salivarius, Streptococcus mitis, Streptococcus sanguis is an potent initiator that causes dental caries/plaques in the Patients receiving fixed appliances in the orthodontic treatment . These dental plaques are more difficult to be removed in the fixed appliances patients. Hence, in our present article, natural products like Acacia catechu willd, Glycyrrhiza glabra, Achillea millifolium, Aesculus hippocastanum, Anacardium occidentale and Eremophila Longifolia that inhibit the growth of oral pathogens, reduce the development of biofilms and dental plaque in orthodontic patients with fixed appliances is reviewed extensively.